LC–UV/MS methods for the analysis of prochelator—Boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH)
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چکیده
منابع مشابه
Structure-Activity Relationships of Novel Salicylaldehyde Isonicotinoyl Hydrazone (SIH) Analogs: Iron Chelation, Anti-Oxidant and Cytotoxic Properties
Salicylaldehyde isonicotinoyl hydrazone (SIH) is a lipophilic, tridentate iron chelator with marked anti-oxidant and modest cytotoxic activity against neoplastic cells. However, it has poor stability in an aqueous environment due to the rapid hydrolysis of its hydrazone bond. In this study, we synthesized a series of new SIH analogs (based on previously described aromatic ketones with improved ...
متن کاملThe antioxidant effects of a novel iron chelator salicylaldehyde isonicotinoyl hydrazone in the prevention of H O injury in adult
Objective: This study was designed to investigate the cardioprotective effect of the novel lipophilic iron chelator salicylaldehyde ? isonicotinoyl hydrazone (SIH) against the oxidative stress exerted by H O through the production of OH radical via the Fenton reaction 2 2 1 1 and to compare them with those of the hydrophilic iron chelator deferoxamine (DFO) and the Na /H exchange inhibitor meth...
متن کاملDirect, derivative spectrophotometric determination of micro amounts of Vanadium (V) by 5-bromo salicylaldehyde isonicotinoyl hydrazone
A simple and highly selective spectrophotometric method has been developed for the determination of trace amounts of V (V) using newly synthesized reagent 5-bromo salicylaldehyde isonicotinoyl hydrazone (5BrSAINH) in aqueous DMF medium. Vanadium (V) forms a brown colored soluble complex with 5-BrSAINH in the pH range 1.0-5.0. The complex shows maximum absorbance at 400nm in the pH range 4.5-5.5...
متن کاملNon-Extractive Spectrophotometric Determination of U(VI) Using 5-Bromo Salicylaldehyde Isonicotinoyl Hydrazone in Environmental, Phosphate Rocks and Fertilizer Samples
A highly sensitive and selective spectrophotometric method was developed for the determination of trace amount of uranium (VI) in water samples in aqueous DMF medium. The uranyl ion forms a pale yellow colored complex with 5-Bromo salicylaldehyde isonocotinoyl hydrazone (5-BrSAINH) in an acidic buffer of pH 5.0. The complex has an absorbance maximum at 395nm, was stable for more than 72 hours. ...
متن کاملThe iron chelator pyridoxal isonicotinoyl hydrazone inhibits mitochondrial lipid peroxidation induced by Fe(II)-citrate.
Pyridoxal isonicotinoyl hydrazone (PIH) is able to prevent iron-mediated hydroxyl radical formation by means of iron chelation and inhibition of redox cycling of the metal. In this study, we investigated the effect of PIH on Fe(II)-citrate-mediated lipid peroxidation and damage to isolated rat liver mitochondria. Lipid peroxidation was quantified by the production of thiobarbituric acid-reactiv...
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical and Biomedical Analysis
سال: 2015
ISSN: 0731-7085
DOI: 10.1016/j.jpba.2014.11.044